Antibody-drug conjugates
-
Antibody-drug conjugatesThe therapeutic potential of antibody-drug conjugates (ADCs)
Ana Reis, PhD
To understand the therapeutic potential of antibody-drug conjugates (ADCs) it is essential to first analyze their mechanism of action, best clinical targets, and current limitations. In this article, we…
-
New and promising trends in therapeutic ADC generation
With the growth of the global market for therapeutic antibody-drug conjugates (ADCs), researchers are set on developing exciting new… Read More
-
What are the most common targets for ADCs?
Currently, dozens of antibody-drug conjugates (ADCs) and immunotoxins have reached the clinic or are under active clinical development. These… Read More
-
Therapeutic ADCs: mechanisms of action and advantages
The therapeutic value of antibody-drug conjugates (ADCs) is widely recognized as highly effective and safe for the treatment of… Read More
-
Bioanalysis of antibody-drug conjugates (ADCs)
The bioanalysis of antibody-drug conjugates remains challenging. However, in recent years, many methodologies have been developed to tackle the… Read More
-
Assessing the pharmacokinetics of antibody-drug conjugates (ADCs)
Pharmacokinetics (PK) and pharmacodynamics (PD) are two interdependent properties of ADCs. Together, they dictate the clinical outcomes of ADC… Read More
-
Key biochemical and biophysical properties of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) are complex molecules. Their key properties are heavily influenced by linker chemistry and antibody conjugation methods. For… Read More
-
Robust methods for the detailed analysis of drug-to-antibody ratio (DAR) and drug load distribution
Average drug-to-antibody ratio (DAR) and drug load distribution are two vital properties of antibody-drug conjugates (ADCs). Over the years, several… Read More
-
Everything you need to know about the generation of antibody-drug conjugates (ADCs)
Antibody-drug conjugates (ADCs) consist of three main elements: an antibody carrier, a cleavable or non-cleavable linker, and a bioactive… Read More
-
Antibody-antibiotic conjugates for therapeutic applications
Antibody-antibiotic conjugates (AACs) are an emerging class of biotherapeutics for the treatment of infectious diseases. With the rise of antibiotic… Read More
