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Human Pepsin A-3(PGI) Recombinant Protein

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Product nameHuman Pepsin A-3(PGI) Recombinant Protein
Uniprot IDP0DJD8
Uniprot linkhttp://www.uniprot.org/uniprot/P0DJD8
Origin speciesHomo sapiens (Human)
Expression systemEukaryotic expression
SequenceMKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVAGSHHHHHH
Molecular weight44.68 kDa
Purity estimated85%
BufferPBS, pH 7.5
FormFrozen
Delivery conditionDry Ice
Delivery lead time in business days5-7
Storage condition4°C for short term (1 week), -20°C or -80°C for long term (avoid freezing/thawing cycles; addition of 20-40% glycerol improves cryoprotection)
BrandProteoGenix
Host speciesMammalian cells
ApplicationsELISA,WB
Fragment TypeFull-length
Spec:NCBI Gene AliasesPGA3
Spec:SwissProtIDP0DJD8.1
NCBI ReferenceP0DJD8
Aliases /SynonymsEC 3.4.23; EC 3.4.23.1; FLJ58952; FLJ77962; pepsin A; pepsinogen 4, group I (pepsinogen A); Pepsinogen A; pepsinogen A4; PGA3; PGA5
ReferencePX-P3000
NoteFor research use only
Datasheet Download
MSDS Download

Publication

  • 1: Mansour-Ghanaei F, Joukar F, Rajpout Y, Hasandokht T. Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran. Asian Pac J Cancer Prev. 2014;15(18):7635-8. PubMed PMID: 25292040.
  • 2: Shafaghi A, Mansour-Ghanaei F, Joukar F, Sharafkhah M, Mesbah A, Askari K, Geranmayeh S, Mehrvarz A, Souti F, Sokhanvar H, Fakhrieh S, Aminian K, Yousefi-Mashhour M, Khosh-Sorur M, Rasoulian J. Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions. Asian Pac J Cancer Prev. 2013;14(6):3931-6. PubMed PMID: 23886209.
  • 3: Abe Y, Iijima K, Koike T, Asanuma K, Imatani A, Ohara S, Shimosegawa T. Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan. J Gastroenterol Hepatol. 2009 Jan;24(1):129-34. doi: 10.1111/j.1440-1746.2008.05691.x. PubMed PMID: 19196398.
  • 4: Korsnes L, Gedde-Dahl T Jr. Genetics of pepsinogen I. Ann Hum Genet. 1980 Jan;43(3):199-212. PubMed PMID: 6767433.
  • 5: Tu H, Sun L, Dong X, Gong Y, Xu Q, Jing J, Long Q, Flanders WD, Bostick RM, Yuan Y. Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study. Int J Cancer. 2015 Jan 15;136(2):425-34. doi: 10.1002/ijc.29005. Epub 2014 Jun 19. PubMed PMID: 24895149; PubMed Central PMCID: PMC4354768.
  • 6: Peitz U, Wex T, Vieth M, Stolte M, Willich S, Labenz J, Jaspersen D, Lind T, Malfertheiner P. Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study. J Gastroenterol Hepatol. 2011 Jan;26(1):82-9. doi: 10.1111/j.1440-1746.2010.06413.x. PubMed PMID: 21175799.
  • 7: Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, Roth MJ, Liu B, Lu N, Giffen C, Qiao YL, Dawsey SM. Serum pepsinogens and risk of esophageal squamous dysplasia. Int J Cancer. 2009 Jan 15;124(2):456-60. doi: 10.1002/ijc.23918. PubMed PMID: 18844222; PubMed Central PMCID: PMC2605159.
  • 8: Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, Ishiguro S, Tatsuta M, Graham DY. Histologic and serum risk markers for noncardia early gastric cancer. Int J Cancer. 2005 Jun 20;115(3):463-9. PubMed PMID: 15688378.
  • 9: Terasawa T, Nishida H, Kato K, Miyashiro I, Yoshikawa T, Takaku R, Hamashima C. Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis. PLoS One. 2014 Oct 14;9(10):e109783. doi: 10.1371/journal.pone.0109783. eCollection 2014. Review. PubMed PMID: 25314140; PubMed Central PMCID: PMC4196955.
  • 10: Zhang XM, Li JX, Zhang GY, Li XH, Gu H. The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China. BMC Gastroenterol. 2014 Jan 3;14:3. doi: 10.1186/1471-230X-14-3. PubMed PMID: 24383519; PubMed Central PMCID: PMC3893538.
  • 11: Huang M, Tang AG, Mu S, Yang JJ, Xiang ZY, Liu B, Yang JJ. Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay. J Clin Pathol. 2014 Apr;67(4):350-4. doi: 10.1136/jclinpath-2013-201942. Epub 2013 Oct 29. PubMed PMID: 24170207.
  • 12: Kutsuma A, Oshida H, Suwa K, Nakajima K. A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men. Clin Biochem. 2014 Jan;47(1-2):126-8. doi: 10.1016/j.clinbiochem.2013.10.003. Epub 2013 Oct 11. PubMed PMID: 24125879.
  • 13: Li P, He C, Sun L, Dong N, Yuan Y. Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease. BMC Clin Pathol. 2013 Sep 2;13(1):22. doi: 10.1186/1472-6890-13-22. PubMed PMID: 24004680; PubMed Central PMCID: PMC3846408.
  • 14: Chae HD, Kim IH, Lee GH, Shin IH, Suh HS, Jeon CH. Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA. Am J Clin Pathol. 2013 Aug;140(2):209-14. doi: 10.1309/AJCPOHXRM5IYXVOC. PubMed PMID: 23897256.
  • 15: Xu Q, Dong QG, Sun LP, He CY, Yuan Y. Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study. BMC Clin Pathol. 2013 Mar 22;13:11. doi: 10.1186/1472-6890-13-11. PubMed PMID: 23521833; PubMed Central PMCID: PMC3635921.

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